Acquisition of angiogenic capacity and neoplastic transformation in the rat mammary gland
Maiorana, A.; Gullino, P.M.
Cancer Research 38(12): 4409-4414
1978
ISSN/ISBN: 0008-5472 PMID: 102422 Document Number: 131030
The ability to induce formation of new vessels was tested in fragments of rat mammary tissue transplanted onto the rabbit iris and observed through the transparent cornea. Virgin, pregnant and lactating glands showed an angiogenic capacity in about 5% of implants. In contrast, mammary carcinomas induced angiogenesis in 75-100% of implants. Fragments of mammary gland previously treated with 7,12-dimethylbenzanthracene or N-nitrosomethylurea but without histological evidence of neoplastic transformation showed an angiogenic response in about 5% of implants.