Mechanism (s) of neoplastic transformation by avian oncogenic retroviruses
Vigier, P.; Biquard, J.M.; Krycève-Martinerie, C.; Lawrence, D.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 174(4): 627-637
1980
ISSN/ISBN: 0037-9026 PMID: 6254623 Document Number: 167310
Neoplastic transformation by avian oncogenic retroviruses, notably by sarcoma viruses, the best known of all, results from the expression of a specific viral gene (oncogene), presumably of cellular origin. The protein coded for by this gene appears to act on different targets controlling the various modified cellular characters. A proteic factor coded for by the cell, and derepressed or activated by the expression of the oncogene, is involved in the maintenance of morphological transformation. This factor is also produced by cells transformed by other viruses or oncogenic agents. Other cellular factors, derepressed or activated, may also act as effectors for other parameters of transformation.