Allogeneic restriction of the delayed inflammatory reaction in the rat
Jungi, T.W.; McGregor, D.D.
Journal of Immunology 121(2): 456-463
1978
ISSN/ISBN: 0022-1767 PMID: 79605 Document Number: 130646
Delayed-type hypersensitivity (DTH) to Listeria monocytogenes was measured in rats that were recipients of syngeneic, semisyngeneic and allogenic immune thoracic duct lymphocytes (TDL). DTH could be transferred only to recipients that shared at least 1 haplotype with the TDL donors. The restriction was expressed in an inability of sensitized lymphoblasts to localize efficiently at antigen injection sites in the pinna of the ear and peritoneal cavity. Failure of allogeneic lymphoblasts to extravasate in more than trace numbers into Listeria-antigen-induced exudates was reflected in an absence of other lymphocyte-mediated expressions of DTH. Thus, lymphocyte-dependent MCA cells to recognize antigen displayed by allogeneic macrophages.