Effect of cimetidine on intrinsic factor and pepsin secretion in man
Binder, H.J.; Donaldson, R.M.
Gastroenterology 74(2 Pt 2): 371-375
1978
ISSN/ISBN: 0016-5085 PMID: 340324 Document Number: 129984
Cimetidine, 300 mg given subcutaneously to normal men 20 to 27 years old, completely inhibited gastric acid, pepsin and intrinsic factor concentration and output stimulated by betazole. Basal output of pepsin and intrinsic factor was not inhibited. The conclusion was that H2-receptor antagonists inhibit betazole stimulation of intrinsic factor output in addition to inhibition of acid secretion.
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