Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B 12
Bélaïche, J.; Zittoun, J.; Marquet, J.; Nurit, Y.; Yvart, J.
Gastroenterologie Clinique et Biologique 7(4): 381-384
1983
ISSN/ISBN: 0399-8320 PMID: 6135642 Document Number: 213584
The effects of ranitidine, a new potent histamine H2-receptor antagonist, on gastric intrinsic factor (IF) secretion and protein-bound cobalamin absorption were evaluated in 6 patients with duodenal ulcer, before, during and after discontinuation of ranitidine therapy. Oral ranitidine (150 mg twice a day) resulted in a non significant decrease of IF concentration and IF output but was responsible for malabsorption of protein-bound cobalamin. This malabsorption was reversible upon discontinuation of ranitidine. These results indicate that occurrence of cobalamin deficiency cannot be excluded during long-term ranitidine treatment and emphasize the need for careful follow-up in these patients.