Class of immunoglobulin deposition and prognosis in lupus nephritis
Donadio, J.V.; Conn, D.L.; Holley, K.E.; Ilstrup, D.M.
Mayo Clinic Proceedings 53(6): 366-372
1978
ISSN/ISBN: 0025-6196 PMID: 651380 Document Number: 129631
In the three major morphologic groups of lupus nephritis--diffuse, focal proliferative, and membranous--glomerular deposition of immunoglobulins is usually a combination of IgG, IgM, and IgA and is not a good indicator of initial renal severity or outcome. In this study of 60 patients with systemic lupus erythematosus and nephritis, patients with exclusive or predominant glomerular deposition of IgG did not have more severe renal disease or a worse prognosis than those with combined IgG-IgM deposition.