Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases
Dhurandhar, R.W.; Nademanee, K.; Goldman, A.M.
Heart and Lung the Journal of Critical Care 7(5): 783-787
1978
ISSN/ISBN: 0147-9563 PMID: 250503 Document Number: 129479
Three patients developed episodes of ventricular tachycardia and/or flutter-fibrillation while receiving disopyramide (Norpace). Syncope was the presenting complaint in all of them. The arrhythmias did not recur after disopyramide was discontinued. The Q-T interval was markedly prolonged in all three patients. One patient developed syncope associated with both quinidine and Norpace therapy. It is postulated that disopyramide, like quinidine, may provoke ventricular flutter-fibrillation in sensitive patients by similar mechanisms.