Effect of cesium, lithium and rubidium on several effects of morphine
Bulaev, V.M.; Ostrovskaia, R.U.
Biulleten' Eksperimental'noi Biologii i Meditsiny 86(7): 42-44
1978
ISSN/ISBN: 0365-9615 PMID: 567072 Document Number: 129457
The effect of chlorous salts of cesium, lithium, and rubidium on the analgetic action of morphine (according to the vocalization test) and also on the pattern of the dependence on it (according to the so-called "two-bottle test") was studied. As shown, the salts under investigation decreased both the algesic reaction threshold and the duration of morphine-induced analgesia; cesium chloride proved most active in this respect. All the compounds studied decrease the morphine preference coefficient. The greatest effect was found in cesium chloride which decreased the morphine preference coefficient 40-fold as compared to the control.