Intranasal tumor of the ethmoid olfactory mucosa in sheep
Yonemichi, H.; Ohgi, T.; Fujimoto, Y.; Okada, K.; Onuma, M.; Mikami, T.
American Journal of Veterinary Research 39(10): 1599-1606
1978
ISSN/ISBN: 0002-9645 PMID: 213993 Document Number: 129230
Intranasal tumours (papillary adenomas or adenocarcinomas) of the ethmoid olfactory mucosa of sheep were investigated by light and electron microscopy. The fine structure of the tumour cells was characterized by the presence of numerous secretory granules. Viral particles, which were morphologically similar to a visna-maedi virus, were detected in all tumour tissues and in 3 of 4 cultures examined. The particles (about 97 nm) had an eccentrically located electron-dense core and numerous spikes on their surfaces. The RNA-dependent DNA polymerase activities in the tumour cells or the cultured cell from the tumour were greater than those in the normal tissues or the cultured cells from the choroid plexus. Viral particles similar to herpesvirus were also detected in one culture.