Physiochemical properties of LIA-0191 a and B antibiotics
Mitrofanova, V.G.; Omel'chenko, V.N.; Petrova, L.I.; Shenin, I.D.
Antibiotiki 23(7): 579-581
1978
ISSN/ISBN: 0003-5637 PMID: 677844 Document Number: 128587
An antifungal antibiotic LIA-0191 was isolated from the mycelium by methanol extraction. It was shown with thin-layer chromatography that it consisted of components A and B. Component A was isolated with collumn chromatography on silica gel, recrystalization from the solvent mixture as a monocomponent crystalline substance. On the basis of the physicochemical and biological properties it was identified with sentacidin. Component B was obtained from preparation LIA-0191 by the method of counter-current distribution and recrystalization from methanol. Comparison of its physico-chemical and biological properties with those of the known purines and pyrimidine pyrrol showed that antibiotic LIA-0191 B is new.