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Clinical relevance of PM-1 antibody and physiochemical characterization of PM-1 antigen

Treadwell, E.L.; Alspaugh, M.A.; Wolfe, J.F.; Sharp, G.C.

Journal of Rheumatology 11(5): 658-662

1984

ISSN/ISBN: 0315-162X
PMID: 6334745
Document Number: 240543
Using an improved immunodiffusion test with partially purified antigen, PM-1 antibody was identified in the serum of 18 patients. In 67% this system was associated with a polymyositis-scleroderma overlap, it occurred less frequently in polymyositis, dermatomyositis and scleroderma, and was not detected in other rheumatic diseases. The predominant clinical features of PM-1 positive patients were muscle weakness, sclerodactyly. Raynaud's phenomenon and pulmonary disease, widespread sclerodermatous features were infrequent. Characterization of the PM-1 antigen showed it to be a heat sensitive, trypsin sensitive acidic protein associated with the cell nucleus and possibly with nucleoli.

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