Pseudohypoparathyroidism type i and vitamin D therapy
Kovarik, J.; Weissel, M.; Neuwirth, G.; Krepler, P.; Willvonseder, R.
Acta Medica Austriaca 5(3): 106-109
1978
ISSN/ISBN: 0303-8173 PMID: 222102 Document Number: 128258
In pseudohypoparathyroidism type I pharmacologic dosis of vitamin-D can correct hypocalcemia. Several authors who had investigated vitamin-D-metabolism in these patients, found impaired renal conversion of 25-hydroxyvitamin-D to 1,25-dihydroxy-vitamin-D. Treatment of 2 patients with pseudohypoparathyroidism type I with vitamin-D-3 and 1 alpha-Hydroxycholecalciferol consecutively resulted in a nonuniform response with regard to the normalisation of serum-calcium. This led us to the conclusion that the disturbances of vitamin-D-metabolism in pseudohypoparathyroidism type I is heterogenous.