A qualitative platelet defect in severe vitamin B 12 deficiency. Response, hyperresponse, and thrombosis after vitamin B 12 therapy
Levine, P.H.
Annals of Internal Medicine 78(4): 533-539
1973
ISSN/ISBN: 0003-4819 PMID: 4632789 Document Number: 57466
Three patients with vitamin B-12 deficiency and profound qualitative platelet abnormalities and 60 healthy controls were studied. After therapeutic doses of vitamin B-12, the platelet abnormalities were corrected, but one patient had a thrombotic episode after 8 days, which further study showed to be not infrequent. It is suggested that platelet function is important in the pathogenesis of haemorrhage and thrombosis.