Lithium: EEG, performance and mood under subchronic therapy
Herrmann, W.M.; Hamann, S.; Fichte, K.; Müller-Oerlinghausen, B.
Arzneimittel-Forschung 28(9): 1520-1521
1978
ISSN/ISBN: 0004-4172 PMID: 582550 Document Number: 128229
In a controlled double-blind trial 2X12 healthy male volunteers were tested during treatment with lithium sulphate (24--36 mval/d) or placebo. Volunteers were tested after one and two weeks' drug intake using the following tests: Quantitative pharmaco EEG, psychological performance and mood scales. In comparison to pacebo, lithium shows increased mistake duration of the pursuit rotor (MLS), decreased flicker fusion threshold and an impairment of mood. The EEG effects (decrease 7--9 cps, increase 20--50 cps) require further clarification.