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Lithium-induced increases in red blood cell choline and memory performance in Alzheimer-type dementia

Brinkman, S.D.; Pomara, N.; Barnett, N.; Block, R.; Domino, E.F.; Gershon, S.

Biological Psychiatry 19(2): 157-164

1984

ISSN/ISBN: 0006-3223
PMID: 6424733
Document Number: 232384
To investigate the relationship between RBC choline and memory in Alzheimer-type senile dementia (SDAT), lithium carbonate was administered to 14 SDAT patients in doses of 400-600 mg/day for 5 weeks. A battery of memory tests was administered at baseline and at weekly intervals. Five patients with serum concentrations below 0.6 meq/liter developed neurotoxicity and were dropped from further analysis. For the remaining patients, Li+ with mean serum concentrations up to 0.6 meq/liter did not alter memory scores significantly. The dramatic increases in RBC choline during the study, however, suggest that RBC choline is not correlated with memory functioning in SDAT.

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