Frequency of thrombocytopenia in psoriasis patients treated with tumor necrosis factor-a inhibitors
Chen, M.; Holland, M.J.; Mir, M.R.; Wong, M.G.; Kelley, B.P.; Grim, K.D.; Bhuchar, S.S.; Hsu, S.
Journal of Drugs in Dermatology Jdd 10(3): 280-284
2011
ISSN/ISBN: 1545-9616 PMID: 21369645 Document Number: 12718
Tumor necrosis factor-? (TNF-?) inhibitors are biologic agents that are currently in wide use for the treatment of psoriasis as well as other inflammatory diseases. Following reports of thrombocytopenia as a potential adverse effect of anti-TNF-? therapy, we performed a retrospective study to determine the frequency of thrombocytopenia, defined as a platelet count <50x109 cells/L, in a cohort of 187 psoriatic patients treated with anti-TNF-? agents over a nine-year period. Although none of our patients met serologic criteria for thrombocytopenia or displayed clinical manifestations of thrombocytopenia, two patients developed platelet counts below 100×109 cells/L. Thrombocytopenia induced by anti-TNF-? agents is a potential adverse effect, it is a rare occurrence that will require further investigation in large, placebo-controlled, double-blind, prospective studies.
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