Biologic therapy for psoriasis: the tumor necrosis factor inhibitors infliximab and etanercept
Weinberg, J.M.; Saini, R.
Cutis 71(1): 25-29
2003
ISSN/ISBN: 0011-4162 PMID: 12553627 Document Number: 564184
During the past several years, one of the major focuses in psoriasis research has been the development of novel biologic therapies for this disease. The aim of these therapies is to provide selective, immunologically directed intervention, with the hope that such specificity will result in fewer side effects than traditional therapies. In this 2-part review, we present an update on the progress of the 4 biologic agents that most likely will be the first available for clinical use: infliximab, etanercept, efalizumab, and alefacept. The structure and mechanism of each drug will be reviewed, as well as the most recent clinical experience and safety data. The first article of this review will focus on the therapies that inhibit tumor necrosis factor alpha (TNF-alpha).