Alpha-methyldopa in schizophrenia
Taylor, P.; Gillman, P.K.; Gaind, R.
Journal of Clinical Psychiatry 39(11): 815-816
1978
ISSN/ISBN: 0160-6689 PMID: 721785 Document Number: 127164
The dopamine hypothesis of schizophrenia suggests that there is a functional excess of dopaminergic activity within the brain of schizophrenics. Alpha-methyldopa interferes with dopaminergic transmission in the central nervous system. We report a case of a schizophrenic in whom, after an overdose of alpha-methyldopa, there was a dramatic and apparently complete resolution of psychotic symptomatology, followed after a few weeks by a sudden return of psychosis.