Facilitation of the effects of L-DOPA by alpha-methyldopa
Uspenskiĭ, A.E.; Korobov, N.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 81(3): 314-316
1976
ISSN/ISBN: 0365-9615 PMID: 986203 Document Number: 100670
Alpha-methyl-DOPA increased the duration of excitation induced by L-DOPA in mice, alpha-methyl-DOPA potentiated the anticataleptogenic activity of L-DOPA in mice pretreated with reserpine or haloperidol. Alpha-methyl-DOPA given to cats 30 min prior to L-DOPA diminished the influence of L-DOPA on the blood pressure and the contraction of the nictitating membrane. When given 4 to 6 hours prior to L-DOPA alpha-methyl DOPA enhanced the reaction of the blood pressure and contraction of the nictitating membrane induced by L-DOPA or dopamine.