Effects of H1 and H2 receptor antagonists on Tetrahymena
Csaba, G.; László, V.; Darvas, Z.
Acta Biologica et Medica Germanica 37(1): 161-163
1978
ISSN/ISBN: 0001-5318 PMID: 100995 Document Number: 126757
In Tetrahymena pyriformis the phagocytotic rate increases in response to histamine, but neither the H1 antagonist phenindamine nor the H2 antagonist metiamide stimulate phagocytosis. The H1 antagonist counteracts the effect of histamine, whereas the H2 antagonist does not. The histamine receptor of Tetrahymena is of H1-type, since it cannot distinguish between histamine and antagonists which are closely related to it chemically. It does, however, distinguish between histamine and the chemically unrelated H1 antagonist, phenindamine. The H2 antagonist does not interact with the receptor.