Anti-edema effects of some H1-receptor antagonists
Rázga, Z.; Gábor, M.
Acta Pharmaceutica Hungarica 61(6): 311-316
1991
ISSN/ISBN: 0001-6659 PMID: 1686138 Document Number: 378799
Experiments carried out with mice of CFLP strain have shown that antihistaminics (chloropyramine, cyproheptadine and dimethindene maleate) significantly inhibit the extents of ear oedema induced by croton oil, dithranol or capsaicin. In rats of Wistar strain, oedema was induced in the hind paw by the subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface on the ear. Preliminary antihistamine treatment inhibited the development of both types of oedema, to statistically significant extent.