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Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate

Pollard, M.; Zedeck, M.S.

Journal of the National Cancer Institute 61(2): 493-494

1978

ISSN/ISBN: 0027-8874
PMID: 277733
Document Number: 126504
Sprague-Dawley and Lobund Wistar rats, which were sensitive and resistant to induction of colon tumors by 1,2-dimethylhydrazine (DMH), respectively, were treated with methylazoxymethanol (MAM), the product of DMH metabolism by the microsomal mixed-function oxidase system. Although the colon tissue in both stocks of rats had similar NAD+-dependent dehydrogenase activities that are considered necessary to activate MAM to an ultimate carcinogen, a 7-fold greater incidence of colon tumors was found in Sprague-Dawley rats, and their tumors were more extensive. The results indicated that the difference in susceptibility to colon tumor induction between the rat stocks was partially related to metabolic activation of DMH and other, as yet undetermined, endogenous factors.

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