The influence of increased dietary linoleate on essential hypertension in man
Vergroesen, A.J.; Fleischman, A.I.; Comberg, H.U.; Heyden, S.; Hames, C.G.
Acta Biologica et Medica Germanica 37(5-6): 879-883
1978
ISSN/ISBN: 0001-5318 PMID: 742306 Document Number: 126500
A pilot study testing the hypothesis of a blood pressure-lowering effect of polyunsaturated fatty acids was made in Evans County, Georgia. A moderate increase of dietary linoleic acid significantly decreased diastolic blood pressure in 8 borderline hypertensive persons, who were otherwise healthy, within 4 weeks. The change was not due to a reduced sodium content of the diet. A significant increase in creatinine excretion and clearance was noted, indicating an improvement in kidney function which might explain the blood pressure-lowering effect of the fat-modified diet.