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Detection of metastatic tumors in nude mice: brief communication

Graham, S.D.; mickey, D.D.; Paulson, D.F.

Journal of the National Cancer Institute 60(3): 715-716

1978

ISSN/ISBN: 0027-8874
PMID: 304899
Document Number: 126106
Homozygous nude (nu/nu) mice were inoculated i.p. with highly malignant human bladder transitional cell carcinoma or human prostate adenocarcinoma. These animals were subsequently given injections of normal human T[thymus-derived]-lymphocytes to restore the known T-lymphocyte deficiency present in homozygous nude mice. Metastatic spread of the prostate and bladder carcinomas was evident in mice given human T-lymphocytes. Although tumor growth was observed at the sites of tumor inoculation, no tumor spread was observed in mice not receiving T-lymphocytes.

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