Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors
Klubes, P.; Connelly, K.; Cerna, I.; Mandel, H.G.
Cancer Research 38(8): 2325-2331
1978
ISSN/ISBN: 0008-5472 PMID: 667828 Document Number: 125572
Some of the factors determining the action of 5-fluorouracil (FUra) against a responsive and nonresponsive rodent tumor were examined. In mice bearing the FUra-responsive solid L1210 dUrd incorporation into DNA in the responsive L1210 tumor and the more rapid recovery in the relatively insensitive Walker 256 tumor correlated with the persistence of FdUMP in the L1210 tumor and its rapid disappearance in the Walker 256 tumor, but peak levels of FdUMP did not relate to tumor susceptibility to FUra.