Ultrastructural basis of changes in the somatosensory-motor cortex of rabbits in general hypothermia
Aznaur'ian, P.A.; Bardakhch'ian, E.A.
Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny 18(5): 43-50
1978
ISSN/ISBN: 0514-7484 PMID: 751354 Document Number: 124422
Ultrastructural and electrophysiologic changes were analyzed in the chinchilla rabbit cerebral cortex in response to general hypothermia. Lowering of the body temperature down to 35.degree. C brings about ultrastructural rearrangement of capillaries, pointing to the development of hypoxia. Progressive lowering of body temperature is accompanied by decrease of dystrophic and degenerative changes of cerebral neurons and synaptic apparatus. Disturbances of microcirculatory hemodynamics appeared to be crucial in the development of ultrastructural changes.