Effect of flunarizine (sibelium) on the arterial blood flow
De Cree, J.; Geukens, H.; Verhaegen, H.
Münchener Medizinische Wochenschrift 120(18): 627-630
1978
ISSN/ISBN: 0341-3098 PMID: 418333 Document Number: 124423
31 patients with intermittent claudication were treated with 10 mg Flunarizine (Sibelium) daily for 6 months. Before the beginning of the trial and after a period of 6 months, a plethysmographic examination was undertaken to determine the reactive hyperemia elicited by a temporary arterial occlusion. 25 patients showed an improvement in at least one of the parameters measured during the reactive hyperemia. Lengthening of the walking distance was also seen at the same time in 24 of these patients. In a further analysis of our results it was shown that in each of the 25 patients those parameters of the reactive hyperemia improved which had deviated furthest from the normal.