Effects of Selenium Supplementation on Iodine and Thyroid Hormone Status in a Selected Population with Goitre in Pakistan
Kandhro, G.A.; Kazi, T.G.; Sirajuddin; Kolachi, N.F.; Kazi, N.; Afr, H.I.
Clinical Laboratory 57(7-8): 575-585
2011
ISSN/ISBN: 1433-6510 PMID: 21888022 Document Number: 12300
Background: Selenium (Se) has an essential role in thyroid hormone metabolism. It has the potential to play a major part in the outcome of iodine (I) deficiency The aim of the present study was to evaluate the Se and I status of biological samples (serum and urine) of 160 goitrous male (GMPs) and 195 female patients (GFPs). The supplemental effects of Se (200 μg/day) and I (100 - 125 μg/day) were evaluated after 6 months. For comparison purposes, non-goitrous subjects of both genders (n = 440) with same age group and socioeconomic status were also selected. Methods: Hydride generation atomic absorption spectrometry (HGAAS) was used to investigate the Se concentration in the biological samples, prior to microwave assisted acid digestion. Quality control for the methodology was established by comparing the results obtained with certified samples with those obtained by conventional wet acid digestion method on the same CRMs and real samples. Results: The mean serum Se concentration was significantly lower, while urinary Se was higher in GMPs and GFPs as compared to control subjects (p Conclusions: It was observed that Se in biological samples of hypothyroid patients can play an important role in determining the severity of the hypothyroidism associated with iodine deficiency. A wide-scale epidemiological study is recommended together with the examination of the potential preventive role of Se supplementation in endemic goiter regions.
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