Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line
Dichter, M.A.; Tischler, A.S.; Greene, L.A.
Nature 268(5620): 501-504
1977
ISSN/ISBN: 0028-0836 PMID: 329148 Document Number: 122817
A cloned line of rat pheochromocytoma cells (PC12) which responds to nerve growth factor (NGF) by cessation of division and extension of neuron-like processes, developed electrical excitability and increased acetylcholine sensitivity in the presence of NGF. This implies that NGF influences the physiological differentiation of certain neural crest derivatives.
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