Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor beta 1 in vitro
Chen, X.; Zheng, S.; Gao, Y.; Dai, H.; Mou, H.; Yang, H.
Chinese Medical Journal 111(6): 546-550
1998
ISSN/ISBN: 0366-6999 PMID: 11245077 Document Number: 490691
To further understand the role of growth regulation of human ovarian cancer cells by transforming growth factor (TGF) beta 1. The cell proliferation, cAMP synthesis, gene expression, and induction of programmed cell death (PCD) in human epithelial ovarian cancer cell line HO-8910 cells exposed to TGF beta 1 in vitro were studied. TGF beta 1 inhibited cell growth and DNA synthesis, and induced G0/G1 arrest in cell cycle. It could also trigger PCD in cells. This induction of PCD may occur within G0/G1 phase. Meanwhile, the assay also showed that TGF beta 1 could inhibit the mRNA expression of c-myc, EGFR and TGF beta 1 genes in cells. TGF beta 1 can not only act as an autocrine to inhibit cell proliferation, but also trigger PCD in HO-8910 cells. These functions may be fulfilled through some specific signal transduction pathways.