Original cutaneous and articular syndrome announcing Hodgkin's disease: a new entity?
Dupré, A.; Fournie, A.; Bergé, M.; Bonafé, J.L.; Miegeville, M.
Annales de Dermatologie et de Venereologie 104(10): 658-661
1977
ISSN/ISBN: 0151-9638 PMID: 610521 Document Number: 122333
Symptoms first appeared on the thenar and hypothenar eminences, on the backs of the distal digital phalanges, and on the periungual regions. Eruptions were red, pseudo-inflammatory and erysipeloid. Symptoms were intermittent for the 1st 2 yr and later became chronic. Corticotherapy resulted in temporary relief of symptoms. Three years after the 1st symptoms, a polyarticular syndrome appeared, characterized by polyarthralgia with articular swelling of the ankles, wrists and hand joints, leading to ankylosis of the large joints. Corticotherapy provided only temporary recession of symptoms. Two years later sclero-nodular type II Hodgkin's disease was diagnosed. Cutaneous symptoms were reduced 80% after 1 yr of radiotherapy and in the absence of corticotherapy. Histological aspects of the affected skin areas are described and a review of the literature on skin syndromes associated with Hodgkin's disease is presented. Suggestions as to the origin of such a syndrome are proposed but its relationship to Hodgkin's disease remains unknown.