Cutaneous granulomas as the first manifestation of Hodgkin's disease
Macaya, A.; Servitje, O.; Moreno, A.; Peyrí, J.
European Journal of Dermatology Ejd 13(3): 299-301
2003
ISSN/ISBN: 1167-1122 PMID: 12804995 Document Number: 555182
We report the case of a 64-year-old male in whom fever, cutaneous rash and hepatomegaly were the first manifestations of Hodgkin disease (HD). Histologically a dense lymphohistiocytic infiltrate with a granulomatous pattern was found in the skin infiltrate. A computed tomography scan revealed hepatosplenomegaly and a small retroperitoneal lymphadenopathy. An hepatic percutaneous biopsy showed a granulomatous infiltration with typical Reed-Sternberg cells. Cutaneous manifestations of HD are briefly reviewed. The authors underline that granulomatous infiltration of the skin as the first manifestation of lymphoma is a very rare feature. We also discuss the possible pathogenic mechanisms of skin granulomas.