Fractures in children treated with methotrexate for leukemia
Stanisavljevic, S.; Babcock, A.L.
Clinical Orthopaedics and Related Research 125: 139-144
1977
ISSN/ISBN: 0009-921X PMID: 880755 Document Number: 121714
Multiple fractures occurred in 7 children treated with methotrexate for leukemia. Non-union or delayed union in spite of adequate immobilization also occurred in children on methotrexate. When the methotrexate was discontinued the fractures usually healed. Methotrexate appears to be a drug which inhibits osteogenesis, and may be promising in heterotopic ossification and related orthopedic conditions.
Document emailed within 1 workday
Related Documents
Lares-Asseff, I.; Paredes, R.; Taboada, C.; Cravioto, J.; Velázquez, M.; Roldán, R.M.; Faisal, A.G. 1988: Pharmacokinetics of methotrexate in children with acute lymphoblastic leukemia Boletin Medico del Hospital Infantil de Mexico 45(10): 671-680Kinahan, J.J.; Otten, M.; Grindey, G.B. 1979: Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine Cancer Research 39(9): 3531-3539
Bernáldez-Ríos, R.; Villasís-Keever, M.A.; Beltrán-Adame, G.; García-Ramírez, R.; Rodríguez-Zepeda, M.C.; Hermida-Gutiérrez, I.; Arias-Gómez, J.; Cruz-Luna, E. 1998: Neurological and psychological sequelae in children with acute lymphoblastic leukemia who had received radiotherapy and intrathecal methotrexate Gaceta Medica de Mexico 134(2): 153-159
Komatsu, K. 1990: Effect of high-dose methotrexate on cerebral metabolic rate of glucose in rats and children with acute lymphoblastic leukemia No to Hattatsu 22(5): 477-482
Sasazaki, Y.; Asami, K.; Utsumi, J. 1992: Transient subacute encephalopathy induced by high-dose methotrexate treatment in children with acute lymphoblastic leukemia and malignant lymphoma Gan to Kagaku Ryoho. Cancer and ChemoTherapy 19(11): 1851-1857
Gerner, T.; Benum, P.; Schistad, G. 1975: Supracondylar fractures of the humerus in children, treated with traction Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 95(28): 1587-1590; 1603
Ringdén, O.; Labopin, M.; Gluckman, E.; Reiffers, J.; Vernant, J.P.; Jouet, J.P.; Harrousseau, J.L.; Fiere, D.; Bacigalupo, A.; Frassoni, F.; Gorin, N.C. 1996: Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin a combined with methotrexate as prophylaxis. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation Bone Marrow Transplantation 18(5): 921-929
Jawish, R.; Saikaly, J.; Ponet, M. 1990: Growth acceleration in orthopedically treated diaphyseal fractures of the femur in children Chirurgie Pediatrique 31(4-5): 235-239
Piggot, J. 1986: Supracondylar fractures of the humerus in children. Analysis at maturity of fifty-three patients treated conservatively Journal of Bone and Joint Surgery. American Volume 68(8): 1304
Ippolito, E.; Caterini, R.; Scola, E. 1986: Supracondylar fractures of the humerus in children. Analysis at maturity of fifty-three patients treated conservatively Journal of Bone and Joint Surgery. American Volume 68(3): 333-344
Esposito, L.; Benedetto, N.; Guerriero, A. 1980: Data on the immunological profile of children with acute lymphoblastic leukemia treated by immunotherapy La Pediatria 88(4): 521-531
Popa, A.V.; Maiakova, S.A.; Kurmashov, V.I. 1997: Therapeutic results in children with acute non-lymphoblastic leukemia treated with modified BFM-87 protocol Voprosy Onkologii 43(4): 414-417
Zajaczkowski, L.; Pituch, A.; Legutko, L. 1976: Immunoglobulin and granulocyte cytochemical reactions in L-asparaginase treated children with acute lymphoblastic leukemia Medecine Interne 14(3): 191-195
Ratomski, K.; Płonowski, M.; Zelazowska-Rutkowska, B.; Zak, J.; Wysocka, J.; Krawczuk-Rybak, M. 2011: Subpopulation of CD14+CD16+ monocytes in the children with acute lymphoblastic leukemia treated with filgrastim Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego 30(176): 111-115
Kaleita, T.A.; Shields, W.D.; Tesler, A.; Feig, S.A. 1989: Normal neurodevelopment in four young children treated with bone marrow transplantation for acute leukemia or aplastic anemia Pediatrics 83(5): 753-757
Fourneau, I.; Broos, P. 1998: Pathologic fractures due to metastatic disease. A retrospective study of 160 surgically treated fractures Acta Chirurgica Belgica 98(6): 255-260
Sutton, W.R.; Greene, W.B.; Georgopoulos, G.; Dameron, T.B. 1992: Displaced supracondylar humeral fractures in children. a comparison of results and costs in patients treated by skeletal traction versus percutaneous pinning Clinical Orthopaedics and Related Research 278: 81-87
Rizzo, S.C.; Balduini, C.L.; Invernizzi, R.; Ricevuti, G.; Fontana, G.; Ascari, E. 1980: Prognostic factors and treatment response in acute lymphoblastic leukemia of children and adults treated with a non aggressive combination chemotherapy Haematologica 65(1): 70-81
Balwierz, W.; Moryl-Bujakowska, A.; Skoczeń, S.; Pawińska, K.; Balcerska, A.; Płoszyńska, A.; Chybicka, A.; Dobaczewski, G.; Juszczak, K.; Wachowiak, J.; Derwich, K.; Kowalczyk, J.; Wiśniewska-Slusarz, H.; Matysiak, Mł.; Krauze, A.; Rokicka-Milewska, R.; Pawelec, K.; Sońta-Jakimczyk, D.; Łuszczyńska, A.; Tomaszewska, R.; Wysocki, M.; Styczyński, J.; Swiatkiewicz, V. 2003: Advances in the treatment of children with high risk acute lymphoblastic leukemia (ALL) treated with modified "NEW YORK" protocols between 1987 and 2002 Przeglad lekarski 60 Suppl. 5: 13-16
Farabow, W.S.; Fulton, J.W.; Fletcher, V.; Velat, C.A.; White, J.T. 1983: Cervical pregnancy treated with methotrexate North Carolina Medical Journal 44(3): 91-93