Possible subdivisions among alpha-adrenoreceptors in various isolated tissues
Barker, K.A.; Harper, B.; Hughes, I.E.
Journal of Pharmacy and Pharmacology 29(3): 129-134
1977
ISSN/ISBN: 0022-3573 PMID: 15074 Document Number: 121071
The ratio (expressed in log10 units) of the equieffective concentrations of (+)- and (-)-noradrenaline values for phentolamine and piperoxan against noradrenaline gave the following values in rat vas deferens (8.22 .+-. 0.07 and 6.72 .+-. 0.03, respectively) and mouse vas deferens (8.31 .+-. 0.05 and 6.53 .+-. 0.07, respectively). The results are discussed in relation to other findings concerning the nature of the .alpha.-adrenoceptor in these tissues. In spite of the absence of any significant difference between the potency of the .alpha.-adrenoceptor in these tissues. In spite of the absence of any significant difference between the potency of the .alpha.-adrenoceptor blocking agents in the 2 species it is suggested that .alpha.-adrenoceptors may not belong to a single homogeneous population but may vary in their characteristics istics from tissue to tissue.