Further comparison of Ca-DTPA and Zn-DTPA for removal of 241Am from beagles
Lloyd, R.D.; Taylor, G.N.; Boseman, J.J.; Mays, C.W.; Atherton, D.R.
Health Physics 33(1): 92-94
1977
ISSN/ISBN: 0017-9078 PMID: 893109 Document Number: 120920
For delayed initiation of decorporation therapy for removal of transuranium elements, the zinc salt of DTPA is at least as efficient on an equimolar basis as is Ca-DTPA, but much safer. Because the toxicity of Ca-DTPA prevents its long-term frequent administration, more radionuclide removal appears likely as a result of frequently repeated therapy with Zn-DTPA over extended periods of time than can be achieved by infrequent administration of Ca-DTPA. In beagles, the efficiency of DTPA treatments appears to be affected by such factors as age and blood loss. Zn-DTPA should replace Ca-DTPA as the treatment of choice, especially for protracted therapy in human cases.