The influence of age on the effectiveness of DTPA in reducing 141Ce retention in rats
Kargacin, B.; Kostial, K.; Landeka, M.
International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 44(4): 363-366
1983
ISSN/ISBN: 0020-7616 PMID: 6605321 Document Number: 215803
The influence of age on the effectiveness of chelation treatment in reducing retention of radioactive cerium was studied in two- and six-week-old albino rats. 141Ce was administered intraperitoneally, followed immediately and after 24 and 48 hours by intraperitoneal administration of the tri-sodium calcium salt of diethylenetriaminepentaacetic acid--Na3(CaDTPA) at 380 mumol/kg body weight. The whole-body retention was determined 2, 4 and 6 days after radiocerium administration, when the animals were killed and the organ retention was determined. The chelation therapy significantly reduced the whole-body retention of radiocerium. This treatment was however twice as effective in older as in younger animals.