Failure of the N-oxodized metabolites of some carcinogenic amines to induce tumors in normal and wounded rat skin
Brill, E.; Radomski, J.L.; Macdonald, W.E.
Research Communications in Chemical Pathology and Pharmacology 18(2): 353-360
1977
ISSN/ISBN: 0034-5164 PMID: 918350 Document Number: 120905
The skin of Osborne-Mendel and Sprague-Dawley rats was treated by repeated topical application of 1- and 2-naphthylamine, 4-biphenylamine and their corresponding N-arylhydoxylamine and nitroso derivatives for 52 wk. The possibility of enhancing the susceptibility of the skin to tumor induction by periodic wounding at the site of compound application was also investigated in the Sprague-Dawley strain. The animals were observed for an additional year after which all survivors were sacrificed. No skin tumors were elicited in any of the rats although a small number of systemic tumors at sites distant from the area of application were observed in the Osborne-Mendel strain. No discernable increase in the sensitivity of the skin as a consequence of wounding to the carcinogenic effect of the compounds tested was observed.