Yolk sac carcinoma grown from rat egg cylinders
Damjanov, I.; Sell, S.
Journal of the National Cancer Institute 58(5): 1523-1525
1977
ISSN/ISBN: 0027-8874 PMID: 67215 Document Number: 120427
Eight-day rat egg cylinders transplanted in toto under the kidney capsules of adult histocompatible recipients gave rise to small nodules composed of parietal yolk sac cells surrounded by Reichert's membrane-like material. These yolk sac cells could grow and give rise to malignant, transplantable tumors identical to mouse yolk sac carcinomas derived from teratocarcinoma. The sera of rats with yolk sac tumors contained elevated concentrations of .alpha.1 fetoprotein.