Correlation of parathormone determination and bone biopsy in primary hyperparathyroidism
Mallet, E.; Ducastelle, C.; Brunelle, P.; Hemet, J.; Deshayes, P.
Revue du Rhumatisme et des Maladies Osteo-Articulaires 44(6): 403-406
1977
ISSN/ISBN: 0035-2659 PMID: 882815 Document Number: 120078
Eleven patients with primary hyperparathyroidism confirmed by histologic examination were subjected to a comparative study of the results of quantitative determination of parathormone and of quantitative bone biopsy. Quantitative radioimmunologic determination of parathormone was carried out with the aid of an N-terminal specific anti serum, while the histologic features studied were the periosteocytic and osteoclastic absorption surfaces. On the basis of a combination of the results of these two techniques, the diagnosis could be made in all the cases studied. A statistically significant correlation was observed between the results of quantitative determination of parathormone and those of histologic examination of the surfaces of periosteocytic lacunae (r = 0.63; p = 0.05).