Plasma bile acids fractionnation by gas-liquid chromatography : application to hepatocellular deficiency investigation
Bereziat, G.; Pepin, D.; Wolf, C.; Polonovski, J.
Pathologie-Biologie 25(8): 559-564
1977
ISSN/ISBN: 0369-8114 PMID: 339169 Document Number: 119792
The level of the 4 major bile acids was measured in plasma using gas liquid chromatography. The enhancement of the level of the primary bile acids was well known during bile duct obstruction. In the case of hepatic diseases, the chenodeoxycholic-cholic acid concentration ratio (CDC/C) was equal or lower than unity when cholestasis occurred rather than hepatic deficiency. When hepatic deficiency developed, the ratio CDC/C was higher than unity. Plasma bile acid fractionation also exhibits a prognostic value. When the ratio CDC/C is very high, it is significant of progressive hepatic deficiency. A high level of lithocholic acid is also a sign of unfavorable prognosis.