Top Abstract Purchase Related
Home
>
Node
>
Subnode

Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee

Fanelli, G.M.; Bohn, D.L.; Scriabine, A.; Beyer, K.H.

Journal of Pharmacology and Experimental Therapeutics 200(2): 402-412

1977

ISSN/ISBN: 0022-3565
PMID: 14250
Document Number: 119760
The saluretic and uricosuric responses elicited by a novel agent, MK-196, have been studied in a great ape, the chimpanzee. This agent is orally active at very low doses and has a prolonged duration of action. Probenecid does not appear to influence the saluretic and uricosuric properties of MK-196. Net tubular secretion of urate was reduced by MK-196. Urinary pH changes did not compromise the efficacy of this new agent. On a dose basis, MK-196 was more saluretic (and uricosuric) than ethacrynic acid or furosemide and possessed a longer duration of action. Because of the marked natriuresis caused by MK-196, some increase in potassium excretion occurred.

Document emailed within 1 workday
Secure & encrypted payments

Zacchei, A.G.; Wishousky, T.I.; Watson, L.S. 1978: The physiological disposition of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in the rat, dog, rhesus monkey, and baboon Drug Metabolism and Disposition: the Biological Fate of Chemicals 6(3): 313-320
Biniecki, S.; Horoszkiewicz, Z. 1974: Synthesis of indolyl-3-acetic acid (1-phenyl-2-3-dimethyl-5-oxo-4-pyrazolyl) amide of 3-indolylacetic acid and N-methyl-(1-phenyl-2,3-3-indolylacetic acid Acta Poloniae Pharmaceutica 31(2): 151-155
Harik, S.I.; Schmidley, J.W.; Iacofano, L.A.; Blue, P.; Arora, P.K.; Sayre, L.M. 1987: On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat Journal of Pharmacology and Experimental Therapeutics 241(2): 669-676
Hagen, V.; Rumler, A.; Klauschenz, E.; Hagen, A.; Heer, S.; Faust, G.; Mitzner, R. 1990: Potential cardiotonics. 7. Synthesis and cardiovascular effects of 5-(4-pyridinyl)-, 6-methyl-4-(4-pyridinyl) and 6-methyl-5-phenyl-substituted 3-cyano-2-aminoalkylamino-pyridines Die Pharmazie 45(4): 240-241
Linari, G.; Spanò, R. 1973: Substituted anilides of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid Arzneimittel-Forschung 23(1): 89-91
Bahekar, S.S.; Shinde, D.B. 2003: Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives Acta Pharmaceutica 53(3): 223-229
Fanelli, O.; Trallori, L.; Mazzoncini, V.; Bianchi, G. 1973: Anti-inflammatory effect of 2-phenyl-5-bromo-indandione (Uridion) with uricosuric acitivity Bollettino Chimico Farmaceutico 112(6): 401-408
Everett, S.A.; Candeias, L.P.; Denny, W.A.; Wardman, P. 1994: Decarboxylation of the antitumour drugs flavone-8-acetic acid and xanthenone-4-acetic acid by nitrogen dioxide Anti-Cancer Drug Design 9(1): 68-72
Wagner, G.; Vieweg, H.; Leistner, S. 1993: Synthesis of 4-methyl-6-phenyl-thieno(2,3-d)pyrimidines with a formamidino- or oxalamidocarbonic acid residue with antianaphylactic activity Die Pharmazie 48(9): 667-669
Sarles, H.; Camatte, R. 1970: Therapeutic action of phenyl-dimethoxy-2'-4' phenyl-methyl-carbinol and of a vesicular endothelium extract in dyspeptic disorders, fat intolerance and steatorrhea Marseille Medical 107(6): 513-516
Keshavarzian, A.; Haydek, J.M.; Zepeda, D.O.; Stinneford, J.G.; Fields, J.Z. 1990: Gastroduodenal ulcers in rats induced by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): requirement for gastric acid secretion and the role of prostaglandins Research Communications in Chemical Pathology and Pharmacology 70(1): 21-48
Kalla, N.R.; Vasudev, M. 1981: Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa Andrologia 13(2): 95-98
Pirie, H.M.; Breeze, R.G.; Selman, I.E.; Wiseman, A. 1976: Indole-acetic acid, 3-methyl indole and type 2 pneumonocyte hyperplasia in a proliferative alveolitis of cattle Veterinary Record 98(13): 259-260
Baruffini, A.; Borgna, P. 1978: 2-amino-3,5-dichloro-benzoic acid and 3-amino-2,5-dichloro-benzoic acid derivatives with phytotoxic action Il Farmaco; Edizione Scientifica 33(4): 281-287
Sladowska, H.; Zawisza, T. 1986: Synthesis and properties of amides of 1-benzyl-3-methyl- and 1-butyl-3-phenyl-7-methyl-4-oxo-2-thioxo (2,4-dioxo)-1,2,3,4-tetrahydropyrido-[2,3-d]pyrimidine-6-carboxy lic acids Il Farmaco; Edizione Scientifica 41(12): 954-963
De Arcangelis, A. 1971: On the use in anti-rheumatic therapy of a new non-steroid anti-inflammatory agent: glucosamide of monohydrated (N-p-chloro-benzoyl-2-methyl-5-methoxy)-indol-3-acetic acid La Clinica Terapeutica 59(3): 229-239
Wagner, G.; Dietzsch, B.; Krake, U. 1975: Gluco- and xylopyranosides of 3-phenyl-4-methyl-(1,2,4)-triazoline- 5-thiones and 3-phenyl-(1,3,4)-thiadiazoline-5-thiones Die Pharmazie 30(11): 694-698
Ching, L.M.; Joseph, W.R.; Baguley, B.C. 1993: Inhibition of antitumor effects of flavone acetic acid by cortisone Anticancer Research 13(4): 1139-1141
Bianco, T.; Centore, R.; Giannetti, P.; Scuri, R. 1992: Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice Drugs under Experimental and Clinical Research 18(3): 93-97
Gemba, T.; Ninomiya, M.; Matsunaga, K.; Ueda, M. 1993: Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6- methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 265(1): 463-467