Detection of recurrent colorectal cancer by 18F-FDG PET/CT comparison with contrast enhanced CT scan
Chiewvit, S.; Jiranantanakorn, T.; Apisarnthanarak, P.; Kanchaanapiboon, P.; Hannanthawiwat, C.; Ubolnuch, K.; Phongsawat, N.; Chiewvit, P.
Journal of the Medical Association of Thailand 96(6): 703-708
2013
ISSN/ISBN: 0125-2208 PMID: 23951828 Document Number: 11974
To evaluate diagnostic performance of 18F-FDG PET/CT in assessment of recurrence colorectal cancer after treatment in Siriraj Hospital. The authors retrospectively studied 48 treated colorectal cancer patients with suspected recurrence who underwent 18F-FDG PET/CT and contrast-enhanced CT (CECT). Clinical information, image follow-up for at least one year, and pathological reports of the patients were reviewed for gold standard Recurrent or metastatic disease was found in 36 of 48 patients. Calculated sensitivity, specificity and accuracy of 18F-FDG PET/CT were 94.4%, 66.7%, and 87.5%. 18F-FDG PET/CT can reduce false positive results of CECT in six patients, thus specificity of 18F-FDG PET/CT was statistically significantly better than that of CECT. Using lesion-based analysis with 65 recurrent sites and 26 non-recurrent lesion, 18F-FDG PET/CT showed better sensitivity 87.7%, specificity 61.5%, and accuracy 80.2 than CECT without statistical significance. 18F-FDG PET/CT overall showed higher sensitivity, specificity, and accuracy than CECT.
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