Non-small cell lung cancer evaluated by first pass dynamic contrast-enhanced 16-slice spiral CT: correlation of tumor vascularity with pathological characteristics
Sun, C-Jin.; Yang, Z-Gang.; Zhou, X-Ping.; Zhou, Q-Hua.; Sun, J-Tao.; Zhang, S-Fu.; Li, J.; Yu, J-Ming.; Zhang, L.
Zhonghua Zhong Liu Za Zhi 29(6): 429-433
2007
ISSN/ISBN: 0253-3766 PMID: 17974276 Document Number: 607179
Objective To investigate the role of first pass dynamic 16-slice spiral computed tomography in the evaluation of tumor angiogenesis in patients with non-small cell lung cancer ( NSCLC) and to assess its importance in predicting pathologic characteristics. Methods The first pass dynamic 16-slice spiral computed tomography was performed in 33 patients with NSCLC. Their peak heights ( PH) were measured with dynamic evaluation software. Their angiogenesis were labelled by anti-CD34 monoclonal antibody. The first pass peak heights (PH) in 33 patients with NSCLC were compared with their microvessel densities ( MVD) and their relationships were assessed by linear regression analysis. Results Among the 33 patients with NSCLCs, the mean first pass PH and MVD of N1-2 were significantly higher than those at stage N-0(P <0. 01). The first pass PH of 33 NSCLC was correlated positively with MVDs. To differentiate stage N-0 from stage N1-2 with 12 HU cutoff value of the first pass PH, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 88.0%, 75.0%, 84.8%, 91.7% and 66.7%, respectively. Conclusion The first pass dynamic contrast enhanced CT may be a predictor of tumor angiogenesis in patients with NSCLC and its pathologic characteristics, and may be helpful to improve the accuracy of lymph node staging with conventional CT.