Cytomegalovirus complement fixation antibody in Guillain-Barré syndrome
Dowling, P.; Menonna, J.; Cook, S.
Neurology 27(12): 1153-1156
1977
ISSN/ISBN: 0028-3878 PMID: 200863 Document Number: 119259
Cytomegalovirus, measles and adenovirus antibodies were measured in the sera of 92 Guillian-Barre patients and 120 controls. Thirty patients (33%) had markedly elevated levels of complement-fixing antibody to cytomegalovirus and in 21, a 4-fold or more alteration in titer was demonstrated. Diagnostic falls in titer were seen in most instances and no significant elevation to the other viral agents was found. The serologic findings reported here suggest that cytomegalovirus may be a common agent involved in the pathogenesis of the Guillain-Barre syndrome.