Hemodynamic changes in burned mice treated with triglycylvasopressin
Wetterlin, S.
Acta Chirurgica Scandinavica 143(7-8): 401-406
1977
ISSN/ISBN: 0001-5482 PMID: 610284 Document Number: 119219
Cardiac output distribution, blood pressure and flow in a carotid artery catheter during the first five days after a standardized 15% third degree burn were studied in groups of mice treated with triglycylvasopressin, and in groups used as controls. All animals received isotonic saline solution amounting to 20% of the body weight twice daily, and the treated groups received in addition triglycylvasopressin (TGLVP), a vasopressin analogue with prolonged effect, 100 microgram/kg body weight twice daily. Cardiac output distribution was determined by the 86Rubidium-technique, and showed in burned animals a decreasing fraction to kidneys and small bowel as well as an increased share to the carcass during the experimental period. These changes were partly counteracted by TGLVP-treatment. Flow in the carotid artery catheter in the treated group far exceeded that in the controls, which might be explained by a lower viscosity of the blood in the treated group.