Restoration of suppressed immunity in burned mice with cimetidine
Zapata-Sirvent, R.; Hansbrough, J.F.; Peterson, V.; Wang, X.W.; Claman, H.
Chinese Medical Journal 98(5): 384-387
1985
ISSN/ISBN: 0366-6999 PMID: 2861976 Document Number: 251014
Thermal injury has been shown to result in suppression of many aspects of immunity. We studied the effect of cimetidine on suppressed cell mediated immunity in burned mice, utilizing a method of quantitating sensitivity to the contact antigen, 2,4-dinitrofluorobenzene. Daily administration of cimetidine resulted in maintenance of normal cell mediated immunity in these otherwise immunosuppressed animals. This effect may be secondary to the antagonism of cimetidine with histamine H2 receptors on suppressor cells. Immunorestoration with cimetidine may improve resistance of the burned host to infectious complications.