Serotonin metabolism in children with different forms of oligophrenia
Martsinkevich, N.E.; Pozdeev, V.K.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 77(3): 416-419
1977
ISSN/ISBN: 0044-4588 PMID: 857530 Document Number: 119106
The authors examined the serotonin and 5-oxyindolacetic acid content in the blood plasma and diurnal urine excretion of 5 OIAA of 37 children from 7--12 years of age with sthenic and asthenic forms of mental retardation. It was possible to show an increase of the initial serotonin and 5-OIAA level in the blood plasma of patients with the asthenic variant. In a prolonged loading with reserpine there was a disturbance of the corresponding adaptive mechanisms. It is assumed that the serotoninergic brain structures may be involved in the pathogenesis and formation of the clinical forms of oligophrenia.