Top Abstract Purchase Related
Home
>
Node
>
Subnode

Serotonin metabolism in normal pregnant women and fetus

Okatani, Y.; Tamura, S.; Sagara, Y.

Nihon Sanka Fujinka Gakkai Zasshi 42(11): 1503-1509

1990

ISSN/ISBN: 0300-9165
PMID: 1703202
Document Number: 356514
To evaluate serotonin (5-HT) metabolism in normal pregnant women and their fetuses, plasma free 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), tryptophan (TRP) and platelet free 5-HT content were determined by HPLC with electrochemical detection. Plasma free 5-HT and TRP concentrations and platelet 5-HT content in pregnant women did not change during pregnancy. In contrast, plasma free 5-HIAA increased after 30 weeks of gestation and reached its peak at 37 weeks. 5-HT, 5-HIAA and TRP concentrations in umbilical cord plasma were significantly higher than in maternal plasma. However, platelet 5-HT content in the fetus was significantly lower than in the mother. No significant correlation was found between 5-HT concentrations in maternal and cord plasma. However, a significant correlation was found between 5-HIAA, concentrations in maternal and cord plasma. The total 5-HT/TRP ratio in cord blood was significantly lower than in the maternal vein. The 5-HIAA/5-HT ratio in cord plasma was markedly higher than in maternal plasma. In conclusion, we demonstrated the patterns of plasma free 5-HT, 5-HIAA, TRP and platelet 5-HT concentrations in normal pregnant women and their fetuses. Furthermore, rapid 5-HT metabolism in the fetus was suggested.

Document emailed within 1 workday
Secure & encrypted payments

Beyers, N.; Odendaal, H.J.; Hough, F.S. 1986: Vitamin D and mineral metabolism in normal pregnancy and in the normal fetus South African Medical Journal 70(9): 549-554
Ito, Y. 1970: Calcium metabolism in pregnant rats, with special reference to correlation between maternal system and the fetus Nihon Sanka Fujinka Gakkai Zasshi 22(11): 1253-1261
Gupta, L.; Dixit, R. 2013: A linear study of pulmonary function tests in normal pregnant and non-pregnant women Journal of the Indian Medical Association 111(10): 666-669
Garcia-Fernandez, N.; Tantengco, V.O. 1974: Urinary riboflavin excretion in normal Filipino non-pregnant, pregnant and lactating women Southeast Asian Journal of Tropical Medicine and Public Health 5(3): 439-446
Lu, S.; Liu, L.; Xu, S.; Ren, S.; Shi, J.; Ji, Y.; Zhang, H.; Li, X.; Qu, L.; Zheng, S.; Cai, S.; Xi, C. 1997: The prospective study of the influence of cytomegalovirus (CMV) infection of pregnant women to fetus Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 11(2): 156-159
Simko, J.; Lukacín, S.; Nicák, A.; Kohút, A. 1973: Serotonin blood level in pregnant women with metrorrhagia in the 2nd half of pregnancy Ceskoslovenska Gynekologie 38(3): 334-336
Kulinska, R. 2014: Haemolytic disease of the fetus and newborn/HDFN/timing in pregnant women and prophylaxis Akusherstvo i Ginekologiia 53(2): 58-63
Mashayekhi, S.O.; Dilmaghanizadeh, M.; Fardiazar, Z.; Bamdad-Moghadam, R.; Ghandforoush-Sattari, F. 2009: Study of awareness among pregnant women of the effects of drugs on the fetus and mother in Iran Health Policy 91(1): 89-93
Medvinskiĭ, I.D.; Kinzhalova, S.V.; Zislin, B.D.; Tsyv'ian, P.B.; Artem'eva, O.G. 2001: Hemodynamic status of the mother and fetus in pregnant women with gestosis during abdominal delivery under different anesthesia methods Anesteziologiia i Reanimatologiia 1: 47-50
Otoka, A.; Otoka, K. 1983: Evaluation of the condition of the fetus and newborn infant after labor induction with prostaglandin E2 in pregnant women with diabetes mellitus Wiadomosci Lekarskie 36(9): 733-739
Shtanova, E.F.; Zakrevskiĭ, A.A. 1972: Effect of a complex of therapeutic measures on the state of the intra-uterine fetus in pregnant women with rheumatic heart defects Pediatriia Akusherstvo i Ginekologiia 4: 50-53
Radder, C.M.; Kanhai, H.H.; de Beaufort, A.J.; Klumper, F.J.; Brand, A. 2000: Evaluation of gradual conversion to a less invasive therapeutic strategy for pregnant women with alloimmune thrombocytopenia in the fetus for prevention of intracranial hemorrhage Nederlands Tijdschrift Voor Geneeskunde 144(42): 2015-2018
Mellina, I.M. 1978: Serotonin metabolism disorders and their relationship to inability to complete pregnancy in women with rheumatism Pediatriia Akusherstvo i Ginekologiia 4: 43-45
Serov, V.N.; Studenaia, L.B. 1980: Diagnostic importance of determining placental lactogen and the iodine metabolic indices for evaluating the state of the fetus in pregnant women with late toxicoses Voprosy Okhrany Materinstva i Detstva 25(5): 57-61
Bulienko, S.D.; Skvarko, S.I.; Kiselevich, R.Sh.; Davydov, L.Ia.; Zav'ialova, K.T. 1973: Simple method for determining urinary estrogenic hormones in pregnant women as an index of the functional state of the placenta and of the intra-uterine fetus Pediatriia Akusherstvo i Ginekologiia 6: 36-38
Zhou, L.S.; Zheng, M.C.; Zhang, G.F. 1994: Bone metabolism in pregnant women Zhonghua Fu Chan Ke Za Zhi 29(3): 157-158; 190-191
Bryner, J.H.; Foley, J.W.; Thompson, K. 1979: Comparative efficacy of ten commercial Campylobacter fetus vaccines in the pregnant guinea pig: challenge with Campylobacter fetus serotype a American Journal of Veterinary Research 40(3): 433-435
Kane, A.; Ba, S.A.; Sarr, M.; Diop, I.B.; Hane, L.; Faye, M.C.; Diouf, S.M. 1997: Echocardiographic parameters in normal pregnant women Annales de Cardiologie et d'Angeiologie 46(1): 21-27
Xiong, Q.; Liang, J.; Shi, G. 1998: Weight gain pattern in normal pregnant women Zhonghua Fu Chan Ke Za Zhi 33(3): 142-144
Kaira, V.B.; Roopam, K.; Khandelwal, R. 1987: Serum copper and ceruloplasmin in normal and pregnant women Indian Journal of Pathology and Microbiology 30(3): 327-332