Effects of piperonyl butoxide on hydroxylation of 2-acetylaminofluorene in hamster liver
Friedman, M.A.; Woods, S.
Research Communications in Chemical Pathology and Pharmacology 17(4): 623-630
1977
ISSN/ISBN: 0034-5164 PMID: 897350 Document Number: 118570
Single i.p. injection of piperonyl butoxide induces a dose dependent and prolonged inhibition of hamster liver acetylaminofluorene hydroxylation. However, this slight inhibition is the result of a 61% inhibition of acetylaminofluorene-7-hydroxylase activity and a 10 fold stimulation of acetylaminofluorene N-hydroxylase activity. This was confirmed by in vivo experiments. The DNA and RNA binding of acetylaminofluorene-C14 increased 2.1 and 2.4 fold, respectively, 16 hrs after treatment with acetylaminofluorene-C14 in combination with piperonyl butoxide.