Insulin response to continuous glucose load in endotoxin shock in the dog
Manny, J.; Rabinovici, N.; Schiller, M.
Surgery Gynecology and Obstetrics 145(2): 198-202
1977
ISSN/ISBN: 0039-6087 PMID: 877838 Document Number: 118309
The insulin response to a glucose load in normal and LD90 Escherichia coli endotoxin-induced shock was studied in dogs. LD90 endotoxin, 1.75 mg/kg of body wt, was injected in the femoral vein and blood glucose plasma inuslin, potassium, pH, pO2 [O2 partial pressure] and O2 were determined before and at different intervals after endotoxin injection. Arterial blood pressure and electrocardiographic changes were continuously monitored and the glucose load was injected before severe hypoglycemia and hypoinsulinemia developed. A group of normal dogs given an identical glucose load served as control. Severe hypoglycemia and hypoinsulinemia developed in the dogs in the control LD90 endotoxic group. Correction of hypoglycemia by eoxgenous glucose was followed by an increase in plasma insulin levels and prolongation of survival. However, insulin levels were significantly lower than in the nonendotoxin glucose loaded group, implying a reduced insulin reaction to glucose stimulation or an increased need and utilization of the hormone in LD90 induced endotoxin shock. The importance of insulin in energy utilization and subsequent recovery in severe endotoxin shock is emphasized.